• Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes 

      Rigg, Emma Kayleigh; Wang, Jiwei; Xue, Zhiwei; Lunavat, Taral; Liu, Guowei; Hoang, Tuyen; Parajuli, Himalaya; Han, Mingzhi; Bjerkvig, Rolf; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Margue, Christiane; Nomigni, Miléne Tetsi; Utikal, Jochen; Miletic, Hrvoje; Sundstrøm, Terje; Ystaas, Lars Andreas Rømo; Li, Xingang; Thorsen, Frits (Journal article; Peer reviewed, 2023)
      Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late-stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis ...
    • TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein 

      Yang, Xu; Zhang, Yan; Xue, Zhiwei; Hu, Yaotian; Zhou, Wenjing; Xue, Zhiyi; Liu, Xuemeng; Liu, Guowei; Li, Wenjie; Liu, Xiaofei; Li, Xingang; Han, Mingzhi; Wang, Jian (Journal article; Peer reviewed, 2022)
      Background The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM proteins ...